Market Summary: In 2020, the global protein crystallization and crystallography market had a value of USD 1.10 billion, and it is anticipated to achieve a compound annual growth rate (CAGR) of 9.2% throughout the forecast period.
Competitive Landscape: The global protein crystallization and crystallography market is highly competitive and includes both regional and global players operating in various regions and countries. Key companies in the market are actively engaged in developing new technologies, mergers and acquisitions, and product innovations to establish a strong presence. Major companies in the market include Rigaku Corporation, Hampton Research, Jena Bioscience GmbH, Bruker Corporation, Molecular Dimensions Ltd., Formulatrix, Inc., MiTeGen LLC, Biogenuix, Arinax Scientific Instrumentation, and HiMedia Laboratories, among others.
Notable Developments: In March 2021, Bruker Corporation launched the PaSER software v.1.1 for plasma proteomics, offering high-throughput 4D proteomics with immediate peptide and protein group identification after experiments. The company also introduced new consumables and software for chemical cross-linking of proteins to study protein structure and interactions.
Factors Driving Market Growth: The continuous expansion of protein crystallization applications to elucidate membrane protein structures, substantial investments in research and development, technological advancements, and the increasing adoption of protein therapeutics are pivotal drivers expected to fuel the market’s revenue growth in the foreseeable future. Additionally, the utilization of protein crystallization techniques has extended into diverse sectors such as biotechnology, pharmaceuticals, and chemicals, which will further contribute to the market’s revenue growth.
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Protein crystallization involves the creation of protein crystals under conditions that do not disrupt the macromolecule’s natural state. This process results in the organized formation of individual protein molecules into crystals. These protein crystals are primarily employed in scientific and industrial applications, particularly in X-ray crystallography studies. Initially used for protein isolation and purification, the significance of protein crystals heightened with the emergence of X-ray crystallography, which offers detailed three-dimensional structural insights into biological macromolecules. This technique remains indispensable for generating atomic-level structural images of such macromolecules, with X-ray crystallography and neutron diffraction being the sole methods capable of achieving this level of resolution. The growing use of protein crystallization for studying membrane protein structures and its effectiveness in protein purification and demonstrating chemical purity are pivotal factors expected to drive market growth.
The increasing demand for protein therapeutics and rapid advancements in protein crystallography technology are expected to be continual growth drivers. Protein crystallography plays a critical role in drug discovery and development, which is especially relevant given the rising incidence of chronic and rare diseases. This has led to an upsurge in drug discovery and development efforts, further boosting the adoption of protein crystallography. However, the high costs associated with equipment and a shortage of skilled professionals are potential hindrances to market growth. Additionally, the absence of standardized protocols for protein crystallization may negatively impact the market’s growth prospects.
Market Dynamics: Driver: The growing demand for protein therapeutics is a primary driver of market revenue. Protein therapeutics have become integral to the healthcare industry due to their specificity and low immunogenicity. Their use in treating diseases like cancer, diabetes, and multiple sclerosis has expanded significantly. The advancement of processes such as protein crystallography and the implementation of standardized protocols are expected to have a positive impact on market growth.
Restraint: The high cost of equipment is a key factor limiting market growth. Advanced techniques like nuclear magnetic resonance spectroscopy and X-ray crystallography require substantial initial investments, which can hinder market expansion. Additionally, a shortage of skilled professionals and a lack of standardized protocols for protein crystallization could negatively affect market growth.
Technology Outlook: The global protein crystallization and crystallography market is divided into two technology segments: NMR and X-Ray crystallography. The X-ray crystallography segment is expected to experience significant revenue growth. It is the most commonly used technique for determining the molecular and atomic structure of protein crystals. Its increasing application for elucidating protein structures and its role in designing drugs for chronic and rare diseases are expected to drive revenue growth in this segment.
Product & Service Outlook: The market is categorized based on product and service into instruments, software and services, and consumables. The consumables segment is anticipated to hold the largest revenue share in the global market. This is attributed to the rising demand for reagent kits and microplates used in proteomics research. The segment includes subcategories like reagents kits, microplates, crystal mounts, and other consumables. The increasing use of reagent kits for various applications in protein chemistry is expected to further boost revenue growth.
End-use Outlook: In terms of end-use, the market is segmented into pharmaceutical companies, biotechnology companies, government institutes, and academic institutes. Biotechnology companies are expected to experience significant revenue growth due to the expanding applications of protein crystallization in genetic engineering, proteomics research, and protein engineering. The pharmaceutical company segment is also expected to grow substantially, driven by the use of protein crystallization in drug delivery processes and the increasing demand for protein therapeutics.
Regional Outlook: North America is projected to dominate the market with the largest revenue share and a CAGR of 33.2% during the forecast period. The growth in North America is attributed to increased investment and funding for proteomics research, the development of structure-based drug candidates, and a focus on protein-based drugs and therapeutics by key manufacturers.
Asia Pacific is expected to experience rapid revenue growth, driven by the growing awareness and adoption of protein crystallization in emerging economies like India and China. The need to identify new ligands for novel drug design and development is boosting the adoption of advanced technologies such as X-ray crystallography and nuclear magnetic resonance (NMR) in understanding protein structure.
Report Scope: The report provides historical data and forecasts revenue growth at a global, regional, and country level from 2018 to 2028. The global protein crystallization and crystallography market is segmented based on technology, product and service, end-use, and region. It covers key parameters such as market size in 2020, CAGR from 2020 to 2028, and revenue forecasts for 2028, among other details.
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